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NF-B1 binds to the promoter of the GLUT-4 gene and suppresses its expression (at both mRNA and protein levels) (114)

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Newman AAC, Serbulea V, Baylis RA, Shankman LS, Bradley X, Alencar GF, et al

This was in contrast to reported CYP2E1 activities in the certificate of analysis

Neuroepidemiology 46:144153 Wallin MT, Culpepper WJ, Nichols E, Bhutta ZA, Gebrehiwot TT, Hay SI, Khalil IA, Krohn KJ, Liang X, Naghavi M (2019) Global, regional, and national burden of multiple sclerosis 19902016: a systematic analysis for the global burden of disease study 2016

The second is the evidence gap : because the blend has never been trialed as a fixed product, every dose, schedule and timeline here is inference from the two component literatures, not a proven blend outcome