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Role of GPX4 in ferroptosis and its pharmacological implication

The NT5C2 germline variants rs72846714 reduce DNA-thioguanine accumulation and interact with acquired NT5C2 relapse mutations that render the leukemic cells thiopurine resistant [107], while the rs35789560 SNP in the FPGS gene is linked to lower levels of long-chained MTX polyglutamates and a higher risk of relapse [112]

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Chronic illnesses like Long COVID and ME/CFS are fundamentally characterized by a severe disruption in cellular energy production, driven by a vicious cycle of oxidative stress and mitochondrial dysfunction

The glutathione-S-transferase is the major enzyme mediating S-glutathionylation by adding GSH to cysteinyl residues of a protein producing PSSG (98)