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Preclinical vs Human Data This section is where honesty matters most

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Such experimental design is motivated for detecting within-subject treatment effects rather than building a generalizable age predictor for new populations

10.1038/nchembio.2261 44 DinalloV.MarafiniI.Di FuscoD.LaudisiF.FranzE.Di GraziaA.et al (2019)

However, substitution of this histidine with an aspartate residue did not alter the mutant -synucleins behaviour as compared to the wild type with respect to this pH dependent conformational change (Moriarty et al., 2017)

To view or add a comment, sign in I definitely agree with the following statement discussing the next phase of potentially making precision psychiatry a reality The proposal is straightforward: Move toward biomarker-driven patient stratification Design more flexible, biology-informed clinical trials Align regulatory approaches with what already works in oncology and dementia Dementia offers a useful reference point