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Although several in vitro studies have demonstrated that SSRI increase aromatase activity and estradiol synthesis 18,19,20,36,37 , in vivo studies have conflicting results with increased or decreased estrogen synthesis and signaling 23

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System Xc - transporter, consisting of Slc7a11 and Slc3a2 subunits, is responsible for the uptake of extracellular cystine in exchange for glutamate [24]

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