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Rose, and Jeffrey P

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This study suggests a role for dialysis in lowering serum ammonia levels and treating hepatic encephalopathy (even if patients may not have a conventional indication for dialysis)

Future research might explore the use of nicotinamide in combined therapy and evaluate activators of NAD-dependent enzymes

Activated B cells can migrate to bone tissue and directly promote osteoclast formation by releasing osteoclastogenic factors: RANKL, TNF, and IL-1, thereby accelerating bone resorption (234)

doi: 10.1186/s12885-015-1964-8