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MTH1 primarily functions to mitigate DNA damage in cells

Furthermore, no clinical trials of ferroptosis-targeted monotherapies or combinations exist for RCC, largely due to insufficient preclinical validation in patient-derived models [e.g., patient-derived xenografts (PDXs) and organoids]

Andreazza AC, Andersen ML, Alvarenga TA, De-Oliviera MR, Armani F, Ruiz FS, et al

Physical, Chemical, and Biological Structures based on ROS-Sensitive Moieties that are Able to Respond to Oxidative Microenvironments

These approaches allow single-cell analyses and the visualization of intercellular heterogeneity (Weill et al., 2019), or the availability of specific and validated antibodies (Lundberg and Borner 2019)