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may reduce malondialdehyde, a marker of cell damage in the liver Improve blood sugar regulating hormone resistance: low glutathione levels are associated with less fat burning and higher rates of fat storing - supplementing may improve both Increase mobility in peripheral artery disease patients: when the peripheral arteries become clogged with plaque, glutathione may improve circulation, enabling patients to walk longer distances Reduce Parkinson's disease symptoms: intravenous glutathione may help reduce tremors and muscle rigidity Reduce oxidative damage in children with autism: these children have higher levels of oxidative damage and lower levels of glutathione in their brains

H 2 S donor GYY4137 has been confirmed to in vivo protect against ischemia-reperfusion injury and attenuate histopathological changes after testicular torsion/detorsion, as well as mediate an increase in antioxidant capacity (89, 92), reduce apoptosis of spermatogenic cells, and increase the expression level of heat shock protein 70 (89), which helps prevent cell apoptosis during heat stress in testicular cells (98), preserve sperm motility in cryopreserved bull sperm (99), and protect proteins and DNA under stress conditions (100)

The mice were euthanized by cervical dislocation prior to mortality and the loss of respiration and reflexes were confirmed before tissue collection

While glutathione is widely known for protecting cells from damage, the team found that cancer cells can hijack it and use it as a nutrient, particularly in environments where other resources are scarce

doi: 10.1016/j.jep.2024.117766 60 JurcauA.SimionA

This leads to the neutralization of their positive electrostatic charge, which may influence protein interactions with substrates, cofactors, and other macromolecules 116,117,118