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They analyzed dozens of experimental and clinical studies, looking at both natural molecules (like NAC, milk thistle, and whey protein) and pharmaceutical approaches (like dimethyl fumarate or bardoxolone)

Rainis T, Maor I, Lanir A, Shnizer S, Lavy A (2007) Enhanced oxidative stress and leucocyte activation in neoplastic tissues of the colon

Under oxidative stress conditions, BH 4 is swiftly oxidized to BH 2 by superoxide anions, particularly peroxynitrite generated by the scavenging of NO by O 2 , and BH 2 can subsequently be regenerated into BH 4 through the dihydrofolate reductase (DHFR) recovery pathway

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A balanced microbiome appears to be essential for healthy brain function, while microbial perturbations can contribute to cognitive deficits, mood disturbances, and neuroinflammation (Sorboni et al., 2022)