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Research has consistently shown that glutathione levels decline with age and are depleted in many chronic disease states including Parkinson's disease, liver disease, heart disease, and alcohol use disorder

There are still several issues to be addressed, especially in cancer research

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The term ligandin was historically associated to proteins characterized in animals, which were able to bind a wide range of hydrophobic ligands, such as steroids, heme and its degradation product bilirubin, carcinogens, and bile salts