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Nanoparticles are encapsulated within intact platelet membranes, platelet-derived extracellular vesicles (PEVs), or hybrid membranes (fused with other cell membranes) [37]

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Specifically, ALDA-1 was shown to be effective in enhancing SOD activity and decreasing the expression of pro-inflammatory and angiogenic mediators in the retinas of diabetic rats of 1-mo disease duration (241)

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Furthermore, the model assumes a fixed timeline for the control problem, which may not reflect the real temporal dynamics of disease progression and treatment response in individual patients