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doi: 10.1016/S1474-4422(05)70326-4, 71

10.1142/S0192415X22500513 156 LinX.-P.CuiH.-J.YangA.-L.LuoJ.-K.TangT

What to Do If One Medication Isn't Working Well Enough If Mounjaro or Wegovy alone reaches a dose ceiling without satisfactory results, your doctor has several evidence-based options: continue escalating the single agent to its maximum recommended dose, switch to a different drug class (such as SGLT2 inhibitors or older lipase inhibitors), or consider a combination approved by clinical evidencesuch as metformin plus GLP-1 therapy for patients with prediabetes

More importantly, metformin treatment was shown to suppress senescence of mouse renal TECs under hyperglycemic condition (182)

This effect is likely mediated through the inhibition of Smad2/3 phosphorylation [101]

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