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NETs induce Fundc1 phosphorylation of endothelial cells, inhibit mitochondrial autophagy and lead to mitochondrial ROS overproduction and lipid peroxidation, thus inducing endothelial cell ferroptosis and microvascular dysfunction

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Walshe, J., Serewko-Auret, M

The results show that all test compounds (8a-8z) showed significant xanthine oxidase inhibitory efficacy (Zhang et al., 2019)

If these side effects are experienced, they are typically minor and easily treatable

Several small molecule inducers have been developed to induce ferroptosis in tumor cells, some of which have been used in clinical studies