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Studies utilizing FDG-PET imaging demonstrate that cerebral hypometabolism correlates with cognitive performance in those at risk of AD and predict the development of mild cognitive impairment, transition from mild cognitive impairment to AD, and development of AD [34]

2.8 Animals Healthy adult Wistar rats, around 7 weeks of age and weighing approximately 180 11 gm, were purchased from the animal husbandry section of the laboratory center at King Saud University, Riyadh, Saudi Arabia

NAD+ is a coenzyme that supports cellular energy production in every cell of the body

Vitamin B12 plays other roles as well

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