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On one hand, it functions as an intrinsic tumor-suppressive mechanism, eliminating early-stage tumor cells or those under specific stresses

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Upon stimulation by cytokines, stress signals, or pathogens, IBs are degraded, allowing NF-B to translocate into the nucleus, where it binds DNA and regulates the expression of genes involved in inflammation, immunity, and apoptosis

and Tamar Weiss Prize Date: May 1, 1993 Event: Location: Dickinson College David M Glasgow Emil R

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Tumor necrosis factor: an apoptosis JuNKie