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Studies suggest that microglial alterations can occur in both early and later stages of the pathology

It is obvious that the results concerning one enzyme may be totally different if mRNA expression, protein expression or activity is assayed, due to time shifts in the changes among these parameters

Nanoparticle-delivered transforming growth factor- siRNA enhances vaccination against advanced melanoma by modifying tumor microenvironment

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These effects can often be minimized by starting with a lower dose and gradually increasing it