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Importantly, this analysis indicated that the majority of targeted genes are not generally required for intestinal gene expression or GFP stability

In this regard, excessive saturated fatty acids intake disrupts many pathways, altering the balance among different PPAR isoforms in the liver, turning it more prone to inflammation and glucolipotoxicity (Valenzuela et al., 2015)

H2O2 exerts dual effects on the activation and the DNA-binding activity of HSF: on the one hand, H2O2 favors the nuclear translocation of HSF, while on the other hand, it alters HSF-DNA-binding activity, most likely by oxidizing critical cysteine residues within the DNA-binding domain

Usman, S

MicrobiologyOpen 9 (10), e1107

doi: 10.1016/j.neuroimage.2012.06.081