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[32] FAD is almost completely buried inside the protein because, unlike a thiol or NADH, it is easily oxidized and must therefore be protected from the surrounding solution

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10.1038/ncomms14329 266 ZhaoC.ChenZ.QiJ.DuanS.HuangZ.ZhangC.et al (2017)

However, considerable effort is still required to understand how these metabolic processes in immune cells interact and contribute to neurodegeneration