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Finally, we confirmed that the PPARa-FSP1 pathway modulated neuronal responses to lipid peroxidation-induced ferroptosis following TSCI, promoting functional recovery

This results in loss of membrane stability and deformability of the RBC, giving the cell its spherical shape (spherocyte)

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Conclusion: These findings indicate sex-specific effects of PFOA exposure on liver and whole-body lipid homeostasis, mediated in part via PPAR dependent mechanisms with important differences between mouse and human PPAR, and identifies hPPARa mice as a valuable in vivo model for toxicological research

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