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Kukkemane K, Jagota A (2020) Therapeutic effects of hydro-alcoholic leaf extract of Withania somnifera on age-induced changes in daily rhythms of Sirt1, Nrf2 and Rev-erb in the SCN of male Wistar rats

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Interestingly, it was reported that during natural sleep or while under anesthesia, the interstitial space increased by 60%, resulting in a prominent rise in the convective exchange of cerebrospinal fluid and interstitial fluid (Xie et al., 2013

A WHO consultation identified the most vulnerable groups as elderly individuals, infants, preschool-aged children, and pregnant or lactating women, due to either increased nutritional demands or impaired absorption capacity ( Addressing the prevention of B12 deficiency and its public health implications requires a comprehensive, life-course approach based on integrated strategies targeting early detection, dietary optimisation, and effective supplementation, in order to mitigate the long-term consequences of inadequate cobalamin status ( Intramuscular (IM) injection is the most invasive and costly administration method, requiring trained personnel and clinical visits