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[DOI] [PubMed] [Google Scholar] 223.Granneman JG, Lahners KN, Chaudhry A

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: L--L----L--L--L---L-

Succinate dehydrogenase B among the table 124:NCIE0808 Mitopreps Hypoxia inducible factor-1 The transcription factor that hypoxia inducible factor (Hif) is made up of and subunit.Under normal oxygen condition, the protein level of Hif1 is very low because of its continuous degradation through a series of translations back incident.Transformation between glycolysis and the oxidative phosphorylation is considered to receive the relative activity of two enzyme PDH and LDH to control usually, the metabolism destiny of said relative activity decision pyruvate.Hif is through inducing the LDH level and controlling this vital bifurcation point through stimulating PDK to suppress the PDH activity.Since this make the acetone acid metabolism from mitochondrion turn to the ability of cytosol, Hif be considered to bio-energy conversion in the cancerous cell to closing heavy moderator