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This is particularly important for diabetic patients with fragile or poorly controlled diabetes

Nat Immunol (2008) 9:50310

Comme dj mentionn, en fonction de la taille du pool de cobalamines, il y a plus ou moins de pertes qui doivent tre compenses si lon veut maintenir peu prs les mmes rserves, et tout cela en tenant compte du pourcentage dabsorption : Note : Concernant la supplmentation pour les vgtaliens/lacto-ovo-vgtariens : le protocole hebdomadaire est souvent considr comme plus pratique, et moins coteux que le quotidien