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Regarding AR-V7, its expression was increased in the xentuzumab + enzalutamide group compared with the enzalutamide-only group (Weyer-Czernilofsky et al., 2020)

Neither is FDA-approved

Round JL, OConnell RM, Mazmanian SK

Radiofrequency tightening treatments are non-invasive treatments designed to counter the skin laxity, sagging, wrinkles, and body cellulite

Citrulline is generally well-tolerated with fewer gastrointestinal side effects than arginine

These gaps highlight the need for future research to move beyond single-cell type and descriptive mechanisms toward systematic dissection of intercellular crosstalk, renal parenchymal cell contributions, and clinical validation