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XL880 has been tested in Phase II clinical trials in metastatic gastric cancer, papillary renal cell carcinoma and head and neck squamous cell cancer ( MP470 is a multi-kinase inhibitor, orally available, that was reported to radiosensitizeglioblastoma cell lines, through the suppression of RAD51, a DNA repair related protein (Welsh et al., 2009)

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Saturation mutagenesis was performed on S586

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However, the application of GSH to rice plants under As stress stimulated the AsAGSH cycle inductions, thereby promoting ROS scavenging, which decreased overall As toxicity ( Figure 7 )