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Orphan G-protein-coupled receptor 124 (Gpr124), a coactivator of the Wnt/-catenin pathway, also impacts angiogenesis (Zhao et al., 2015a)

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Although the results are largely credited to the selenium treatment, it should be noted these patients were concurrently receiving chemotherapy, oxygen therapy, vitamins E and A, dietary changes, and psychotherapy

They concluded: "In conclusion, we have proposed the MINE score, which is an easy-to-use echocardiographic classification of severity of MMVD, proven to be clinically effective since it is associated with survival