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Route of administration to bypass the BBB : Intrathecal administration of drugs enables the delivery of therapeutic products to the cerebrospinal fluid, which can be distributed throughout the ventricular system and eventually enter the brain parenchyma

Freeman and Company, New York, p 732 Sujayev A, Garibov E, Taslimi P, Gulcin I, Gojayeva S, Farzaliyev V, Alwasel SH, Supuran CT (2016) Synthesis of some tetrahydropyrimidine-5-carboxylates, determination of their metal chelating effects and inhibition profiles against acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase

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The clinical experts have suggested a series of metabolic alternations that in concentration would explain the poor outcome that an ICU patient with this depletion present (Figure 8)

doi: 10.1074/jbc.M805711200

Any breakdown in the homeostatic balance between ROS formation and antioxidant capacity in the seminal plasma of human semen leads to OS when highly reactive ROS overwhelms the antioxidant defense systems (66)