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As of May 2026, BPC-157 remains on the FDAs Category 2 restricted list, pending advisory-committee review

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This activity was owing to increased expression of pyruvate carboxylase (Lee et al., 2013), or reduced expression of glutamate transporter-1 and K ir 4.1 K + channels, which are key regulators for the clearance of extracellular glutamate and maintenance of membrane potentials, respectively (Behrens et al., 2002