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The curve expands upon the earlier P-F (Potential Failure to Functional Failure) curve, first introduced by Nowlan and Heap in 1978, by adding the "Design" and "Installation" phases

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These diseases include rheumatoid arthritis, celiac disease, and lupus

Watanabe et al

This program can be triggered either by DNA-bound GR/MR since glucocorticoid can cross cell and nuclear membranes, or by synaptic GR/MR that can translocate to the nucleus after glucocorticoid binding

This is achieved through a variety of options that are targeted toward the individuals unique circumstances