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6a, TNF supplementation in the media for 8 h induced robust gene expression levels of both c-FLIP and c-IAP, which were significantly downregulated by a 2-h pretreatment with H 2 O 2 , BCNU, or diamide

Cancer Res, 58, 25682575

Our findings offer new insights into highly sophisticated systemic defense systems evolved by plants to defend against herbivory and pathogen invasion