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Additionally, we are finalizing, with modifications, an amendment to 427.302(e)(4), to use the first month of the first full calendar quarter after the drug is assigned a billing and payment code other than a NOC code as the benchmark period CPI-U for a Part B rebatable drug that was billed under a NOC code during the calendar quarter beginning July 1, 2021, or the third full quarter after such drug's first marketed date, whichever is later

Across these trials, tirzepatide delivered dose-dependent improvements in glycemic control and body weight, often surpassing comparators like semaglutide and dulaglutide (43)(44)