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Use documented guidelines to guide dosage planning decisions

The formation of citric and alpha-ketoglutaric acids in the mammalian body

It can interact with positively charged molecules by electrostatic interaction

Many chemotherapeutic drugs induce senescence in tumor cells, exposing them to an immune surveillance system for elimination

Importantly, inefficient elimination of mitochondria in red blood cell (RBC) precursors of sickle-cell disease patients results in mitochondrial retention in mature erythrocytes with consequent increased ROS generation and accelerated hemolysis [60, 61]

DUBs can be further categorized into two classes, the Cysteine proteases and the zinc-dependent metalloproteases (Todi and Paulson, 2011)