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A study suggested that in GCH1-deficient mice, BH4 could still accumulate with age, which was associated with the production of BH4 by specific gut microbiota, such as intestinal Actinobacteria [118]

Li ZG, Duan XQ, Min X, Zhou ZH

There's also intriguing data on the nervous system -- BPC-157 has shown neuroprotective effects in animal models of traumatic brain injury and spinal cord damage, and some research suggests it modulates dopamine and serotonin pathways in ways that could affect mood and addiction

This work was also supported by NIH R01 EB016089, R01 EB023963, and P41 EB031771.

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It is also noteworthy that mutations in genes involved in FAD metabolism have been implicated in rare diseases, including mutations in the vitamin B2 transporters ( SLC52A1 SLC52A3 ) and FLAD1 (ref