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Many factors can cause nonspecific binding

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Similarly, the DA increase observed at 3 months was no longer significant in mutants compared with controls at 8 months, when apoptosis pathways increased (Supplementary Table 1d)

20 It is worth noting that gene polymorphisms of liver metabolic enzymes, such as UGT , SULT , and CYP2E1 , and some co-existing diseases, such as viral hepatitis, acute and chronic malnutrition, and nonalcoholic fatty liver disease, may increase the susceptibility to APAP-induced liver injury, even at a therapeutic dose

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