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doi: 10.1038/s41418019-03523 94 YangMChenPLiuJZhuSKroemerGKlionskyDJet al

In general, free S100 protein can act as a DAMP by binding to receptors such as the receptor for advanced glycation end products (RAGE) or TLR (Figure 4)

A recent study in mature rat hippocampal neurons showed that l-carnitine and ALC protected the mitochondrial membrane potential and countered the decline in oxygen consumption rates and the rise in mitochondrial fragmentation provoked by A1-42 [81]