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[2] BDNF is a profoundly universal point of convergence for mechanistically explaining essentially all known activities that promote brain health

Brown fat AKT2 is a cold-induced kinase that stimulates ChREBP-mediated de novo lipogenesis to optimize fuel storage and thermogenesis

( I ) Histogram showing the acrophase distribution of rhythmic metabolites in plasma samples of Ctrl and cKOt mice

This method has been described in detail by Alves et al

[20] Antioxidant defence systems, including superoxide dismutases, catalase, peroxiredoxins and glutathione peroxidases, convert reactive oxygen species such as superoxide and hydrogen peroxide into less reactive products, and low-molecular-mass antioxidants such as glutathione, ascorbate and tocopherols further limit oxidative chain reactions