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Due to high levels of a UV-A chromophore in the lens (122) that mimics that of the human UV filter, a similar pattern of lens GSH distribution with lower levels of GSH in the nucleus relative to the cortex (183), and a similar age-dependent pattern of nuclear disulfide formation (184), it is proposed that guinea pigs are the best non-primate model currently available for the study of UV-A exposure and cataract ( However, while there are many benefits to the use of guinea pigs as a model of human UV exposure, it is also important to consider inconsistencies between humans and guinea pigs

Heliyon 10(3):e24857

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