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Additionally, MEGA-PRESS GSH quantification presents inherent methodological challenges: the relatively long TE (79 ms) required for J-difference editing results in T-weighted signal attenuation, and the low concentration of GSH (~ 12 mM) combined with spectral overlap necessitates careful interpretation of absolute values

Besides, linsitinib fails to show activity in patients with metastatic prostate cancer, locally advanced or metastatic adrenocortical carcinoma [158, 161]