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Animal studies administering 5-Amino-1MQ orally to diet-induced obese mice have shown dose-dependent reductions in body weight (typically 10-30% reduction compared to vehicle-treated obese controls over 4-12 week treatment periods), with the weight loss primarily reflecting fat mass reduction while lean mass is preserved or even increased

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Molecular pathology: MP , 54 (5), 311316

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(2) Abid MSR, Qiu H, Tripp BA, de Lima Leite A, Roth HE, Adamec J, Powers R, Checco JW