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Medical Hypotheses, 84 , 589592

Moreover, by integrating newly developed organoid cultures, such as 3 dimensional liver organoids, into drug development process could prove to be instrumental to assess the antiviral activity in complex in vitro model [64, 91]

Supplementary Video 4 (download MOV Colocalization of lyso-H 4 B-PMHC (10 nM, top row, cyan) and lyso-H 4 B-CH 3 (10 nM, bottom row, cyan) with lysoTracker Deep red (75 nM, magenta) in HT-1080 cells, imaged under HILO modality

in fact, these treatments promoted UPR mt and mitophagy, restoring mitochondrial and organismal function, and even stimulated the reduction of amyloid deposits in these models 114

We identified the homeobox HHEX as the most enriched transcription factor in the zF and established its role in defining inner zF cell identity