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If patients reported improvement (from mild to substantial), they were regarded as responders

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At the peak of demyelination, there was a significant upregulation of pro-inflammatory cytokines, including TNF- (p = 0.0090), IL-6 (p = 0.0075), and IL-17 (p = 0.0017), with IL-1 showing a similar trend that did not reach statistical significance (p = 0.2011)

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