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Subsequent serum biochemical assays demonstrated that the concentrations of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), indicative of liver function impairment, as well as urea (UREA) and creatinine (CREA), indicative of renal function impairment, did not exhibit statistically significant differences between the treatment groups and the control group ( Figure S27b )

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Women on hormone replacement therapy should consult their prescribing physician at least annually to assess whether continued hormone therapy is appropriate

We assessed six rodent models of ASD as part of this translational study, and showed that the abnormality seen in individuals with ASDnamely a striatal glutamate deficitwas recapitulated in VPA-exposed mice, Nlgn3 R451C KI mice, and Nlgn3 KO rats

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