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Instead, it binds covalently to the selenocysteine active site of GPX4, inactivating the enzyme and triggering lipid ROS accumulation (8284)

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These pro-inflammatory cytokines activate neutrophils, which release myeloperoxidase and catalase, giving way to an oxidative burst with implications on local tissue damage and initiating ECs junctional disassembly [118,119,120]

27 patients (2.7 %) were HDV RNA positive, 80% were male, mean age 44yo (SD15), 74% had advance fibrosis or cirrhosis and 3 patients (11%) were co infected by HIV