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discovered that restricting dietary intake of lysine in patients was well tolerated and resulted in a substantial reduction in plasma and CSF levels of -AASA and P6C, resulting in seizure control and some improvement in developmental milestones [25]

Generally safe, side effect is usually constipation (which you may already have)

In a phase 2 study, comparing the results of the empagliflozin arm to the control arm showed a significant improvement in the electrophysiological studies and a significant decrease in the pain score and the mean serum levels of neuron-specific enolase and malondialdehyde in patients with DPN

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In response to additional comments, we explain more about our evaluation of the evidence submitted for both applications

Audrito, V., Manag, A., Gaudino, F., Sorci, L., Messana, V., Raffaelli, N., & Deaglio, S