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Organs such as brain and heart, with high rates of oxygen consumption and limited respiration levels, are particularly vulnerable to this phenomenon, hence partially explaining the high prevalence of cardiovascular diseases (CVD) and neurological disorders in elderly (Corbi et al., 2008)

210 In a randomized, double-blind, placebo-controlled trial that included 81 healthy subjects, those who received 400 mg ebselen twice daily for four days, beginning two days before testing, exhibited 68% less of a temporary decrease in hearing 15 minutes after an experimental loud sound exposure compared with placebo

Numerical and graphical optimization were employed for identifying the optimized composition

doi: 10.1016/j.cell.2009.08.017

the more significant of these being the pH and the concentration of metal ions in the local microenvironment

The Wald test was used to determine Fishers z value, and the combined results were shown as estimates