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Neutrophils, the most abundant leukocytes, are involved in killing pathogens

Localized to the plasma membrane, FSP1 utilizes NAD(P)H to reduce CoQ10 to CoQ10H 2 or ubiquinol, which acts as a lipophilic radical-trapping antioxidant that can effectively interrupt the lipid peroxidation chain reaction, thus establishing a defense line on the plasma membrane independent of the GPX4GSH system (Mao et al., 2021