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doi:10.1016/j.neubiorev.2021.02.040

Notably, the DEGs were significantly enriched in signaling pathways associated with mitochondrial function, such as mitochondrial membrane organization, regulation of mitochondrial membrane permeability, and mitochondrial ATP synthesis coupled proton transport (Fig

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Structural view of the Ran-Importin beta interaction at 2.3 A resolution

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Thus, a direct virus-related injury to cholangiocytes may cause cellular injury-related GGT release and inflammation-related biliary obstruction, both favoring preferential GGT elevation in circulation in severe cases of COVID-19