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10.1186/s40478-016-0316-5 258 ORourkeJ

Ann Surg 242(3):392-9

Previous studies suggest that GCL is localized to the chloroplasts and GS is localized both to chloroplasts and cytosol in plant cells (Hell and Bergmann, 1988, 1990)

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For deficiency without neurological involvement or for borderline levels, oral supplementation with high-dose cyanocobalamin (1000-2000 mcg daily) is often effective, as approximately 1% of an oral dose is absorbed through passive diffusion even in the absence of intrinsic factor