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The severity of the allopurinol hypersensitivity syndrome is a reminder that specific criteria must be used to decide which patients should be treated with allopurinol (See Table 4: Reasons to Use Medication to Lower Uric Acid )

CYP2D6*10 and *41 have reduced enzymatic activity, whereas CYP2D6*3 , *4 , and *5 have no enzymatic activity

This process not only impairs cellular energy metabolism but also exacerbates oxidative stress, further contributing to neuronal death (12,13)

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Whole-Genome and RNA Sequencing Reveal Variation and Transcriptomic Coordination in the Developing Human Prefrontal Cortex

Although various carriers have been exploited for delivery of neurotherapeutics, target-orientated nanotherapeutic delivery is more precise for brain targeting