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Metal-phenolic nanomedicines regulate T-cell antitumor function for sono-metabolic cancer therapy

In the inflamed tissue microenvironment of IBD patients, infiltrating immune cells, together with the energy requirements of resident epithelial and stroma cells limit the available oxygen 14 , and together with a reduced blood supply, these changes contribute to hypoxic conditions in chronic inflammation 15

Hursting SD, Lavigne JA, Berrigan D, Perkins SN, Barrett JC (2003) Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans

Among these, peptide YY (PYY) plays a critical role by promoting the secretion of LH and FSH, thereby participating in the neuroendocrine regulation of the HPO axis 262,340,344

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