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These approvals bolster the importance of glutamate in depression and represent an exciting breakthrough in contemporary psychiatry, providing new avenues of treatment for patients as first-line therapy or with either poor response or unacceptable side effects to monoaminergic antidepressants

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Gouaze V, Mirault ME, Carpentier S, Salvayre R, Levade T, Andrieu-Abadie N

PMID 31969167

Additionally, histidines imidazole group is capable of scavenging free radicals directly, further emphasizing its role as a molecular antioxidant [95]