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, 18 , 572-578, doi: Ristoff, E., and Larsson, A

This Review discusses the latest findings regarding the role of leptin in the immune system and metabolism, with particular emphasis on its effect on autoimmune and/or inflammatory rheumatic diseases, such as rheumatoid arthritis and osteoarthritis

Cross-cancer comparisons reveal that although the SSP serves conserved functions in sustaining one-carbon unit supply and mediating therapeutic resistance across cancer types, the remarkable heterogeneity of its upstream regulatory mechanismsincluding Kras/FGFR3 mutations, MYC-mediated stemness maintenance, and m6A epigenetic modificationsdictates that therapeutic strategies must be precisely tailored